Tretinoin is the generic name for synthetic, first-generation all-trans-retinoic acid. Topical tretinoin first arrived on the dermatology scene in the 1960s. It is a prescription drug approved to treat acne, and in a few other FDA-approved products (which does not apply to our tretinoin products) as an adjunctive agent to treat fine facial wrinkling for patients who use comprehensive skincare and sun avoidance programs.